Symbol
Name
ID

Tgfb1
transforming growth factor, beta 1
MGI:98725

Phenotype annotations related to digestive/alimentary system

Darker colors indicate more annotations

Human Phenotypes

Gastrointestinal hemorrhage

Hematemesis

Melena

Esophagitis

Rectal prolapse

Steatorrhea

Ileus

Meconium ileus

Diarrhea

Vomiting

Functional abnormality of the gastrointestinal tract

Dysphagia

Gastroesophageal reflux

Disease(s) Associated with TGFB1

cystic fibrosis

eosinophilic esophagitis

factor VIII deficiency

multiple myeloma

Mouse Phenotypes

colonic necrosis

gastric necrosis

abnormal enterocyte proliferation

abnormal intestinal epithelium morphology

abnormal enterocyte morphology

abnormal crypts of Lieberkuhn morphology

crypts of Lieberkuhn abscesses

abnormal colon morphology

gastric ulcer

increased large intestine adenocarcinoma incidence

increased anal adenocarcinoma incidence

increased colon adenocarcinoma incidence

increased rectum adenocarcinoma incidence

increased stomach tumor incidence

increased gastric adenocarcinoma incidence

diarrhea

large intestinal inflammation

cecum inflammation

colitis

proctitis

small intestinal inflammation

salivary gland inflammation

stomach inflammation

Availability

Mouse Genotype

Tgfb1^tm1Doe/Tgfb1^tm1Doe

Tgfb1^tm1N/Tgfb1^tm1N

Tgfb1^tm1Rif/Tgfb1^tm1Rif

Tg(Lck-cre)548Jxm/?
Tgfb1^tm2.1Doe/Tgfb1^tm2.1Doe (conditional)

B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv
Tg(Cd4-cre)1Cwi/0 (conditional)

B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv
Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ (conditional)

Tgfb1^tm1Doe/Tgfb1^tm2.1Doe
Tg(Lck-cre)548Jxm/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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